Nicotine
In 1998, scientists announced the identification for the first time of a key
brain chemical related to nicotine addiction, in the journalNature. The
researchers worked at the Pasteur Institute in Paris, Karolinska Institute in
Stockholm and the research arm of Glaxo-Wellcome in Geneva. The addictive
nature of nicotine is related to release of
dopamine, a neurotransmitter chemical in the brain. The scientists had found
the first of 11 subunits, or molecules, of the nicotine receptor in the brain
of mice. Mutant mice lacking the b2 subunit in their brains did not react to
nicotine. Humans have the same so-called b2 subunit. This is a step toward to
designing a drug to block the receptor, and produce new smoking-cessation
drugs.
In 1996, the Calypso was accidentally rammed by a barge and
sank in Singapore Harbour. Jacques Cousteau had
used the Calypso as his oceanographic research vessel since
1950. It was a former British minesweeper, HMS J-826, that served as a ferry
off Malta after WWII. To finance his voyages throughout the world’s oceans, he
enlisted media attention by writing books and film-making, including a
television series, “The Undersea World of Jacques Cousteau.” Over the years, he
made modifications, including an underwater observation bubble and a helicopter
landing pad. He was aged 85 when he lost the ship and was attempting to raise
funds to replace it, but died 25 Jun 1997. As of 2014, Calypso II was
still a wish. The Calypso was raised and taken to France to
restore as a museum.
In 1940, George
Stibitz's Complex Number Calculator was functional. He was a
research mathematician at Bell Laboratories, who worked on its construction
from Apr 1939, assisted by Samuel Williams. Later known as Bell Labs
Model I Relay Computer, it used telephone relays and coded decimal numbers as
groups of four binary digits (bits) each. It has been called the first
electromechanical computer for routine use. A demonstration of its
ability in remote computing was given on 11 Sep 1940, when messages were
exchanged by phone lines between teletypewriter operators. Calculations
suggested by attendees of the American Mathematical Society's meeting at
Dartmouth College, Hanover, New Hampshire were communicated to an attendant at
the keyboard of Stibitz's calculator in New York.
In 1938, the superfluidity of liquid helium at a temperature near absolute zero
was reported in the
journal Nature. Two articles were published together since the
discovery had been made independently by both P.L. Kapitza in
Moscow, Russia, and also by Jack Allen
with Don Misener in Cambridge, England. Kapitza was eventually awarded a share of the Nobel
Prize in Physics in 1978 for his inventions and discoveries in the area of
low-temperature physics.
Spectrophotometer
In 1935, the first U.S. patent for a spectrophotometer was issued to Professor
Arthur Cobb Hardy of Wellesley, Mass. (No. 1,987,441) which he called a
“photometric apparatus.” It could detect two million different shades of
colour and make a permanent record chart of the results. The patent was
assigned to the General Electric Company of Schenectady, N.Y. which sold the first machine
on 24 May 1935. It used a photo-electric device to receive light alternately
from a sample and from a standard for comparison. It eliminated any need for
the two beams (from sample and from standard) to travel different optical paths
which in previous designs could introduce inaccuracies if one path varied from
the other.
In 1894, Black American inventor Fredrick J. Loudin was issued a U.S. patent
for a "Key Fastener" (No.512,308). The invention was
a device designed to attach to the knob-shaft or door-handle above the key-hole
and fasten the door key in place in the lock by engaging with the eyed-end of
the key to keep it from being turned in the lock. As the patent described, this
would prevent disengaging the key, as might otherwise be done by a burglar from
the outside of the door with some suitable implement, inserted through the
key-hole. Loudin's first patent was issued 12 Dec 1892 for a window
"Fastener for the Meeting Rails of Sashes" that permitted the window
to be locked either closed or partially opened (No. 510,432).
Hollerith
tabulating machine
In 1889, Dr. Herman Hollerith received
the first US patents for a tabulating machine (No. 395,781, -2, -3) which he called the
"Art of Compiling Statistics". His system was designed to record separate
statistical items by means of combinations of holes in a punched card to carry information about
an individual. The information contained on numerous cards could then be tallied by passing the
cards through electrical counters operated by electromagnets. The patent
described its application in compilation of the statistics of the population
for the U.S. Census. The first extensive application of this system was for the
1890 census counting data items such as age, sex, occupation, etc., of which
tallies could be made in combinations such as how many males of certain ages.
Leather
tanning
In 1884, the first U.S. patents for tanning hides and skins through the action
of a metallic salt were issued to Augustus Schultz of New York City. His
invention of a chrome tanning process enabled leather to be tanned thinner and
stronger than by vegetable tanning. (Nos. 291,784 and -5)
In 1872, a second U.S. patent was issued to Black American inventor Thomas
Elkins for a a new article of chamber furniture which he designated a
"Chamber Commode" (No. 122,518). It provides a combination
of "a bureau, mirror, book-rack, washstand, table, easy-chair, and
earth-closet or chamber-stool," which might otherwise be constructed as
several separate articles. Previously, a patent had been issued to Elkins on 22
Feb 1870 for a "Dining, Ironing Table and Quilting Frame Combined"
(No. 100,020). Another patent
was subsequently issued on 11 Apr 1879 for a "Refrigerating
Apparatus" for "food or corpses," which provides a convenient
container and method of chilling using the evaporation of water. (No. 221,222).
In 1838, the first telegraph message in the U.S. in which letters were
represented by dots and dashes was transmitted. The message was:A patient
waiter is no loser. The communications system was invented by Alfred Vail
of Morristown, N.J., in Sep 1837. A public demonstration was given at New York
University using a circuit of ten miles on 24 Jan 1838.
In 1790, President George Washington in his State of the Union address urged the second session of the First U.S. Congress
meeting in New York to support the introduction of new and useful inventions
from abroad, and recognize the skill and genius of U.S. inventors. Within days,
both the House set up a committee to draft a patent statute, because the
congressmen agreed that promotion of science would contribute to the security
of a free government. By 17 Feb 1790, the bill was given its first reading in
the House, and reconciliation of amendments from the Senate was complete by 5
Apr 1790. George Washington signed the statute
into law on 10 Apr 1790. The first patent was granted 31 July 1790 to Samuel
Hopkins for a method of making potash and pearl ashes





